Recognition of the p53 Null Staining Pattern Increases the Detection of p53 Alterations in Inflammatory Bowel Disease-Associated Carcinomas

Colorectal cancer (CRC) occurring in the setting of Inflammatory Bowel Disease (IBD) is relatively uncommon. Mutations in p53 have been found in these cancers, and have been proposed as a possible genetic marker with utility in detection of these cancers and their precursor dysplasias. We undertook this study to determine the frequency of p53 null alterations, a recently observed pattern that has not previously been described in colitis-associated neoplasia.

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