Over 15,000 Sessile Serrated Polyps: Slow Progression to Low-Grade and High-Grade Dysplasia in a Large Nationwide Population.

Richard H. Lash and Robert M. Genta, Miraca Life Sciences Research Institute, Irving, TX

Sessile serrated polyps (or adenomas, SSAs) are recognized as precursors to microsatellite unstable adenocarcinomas. We have reported the prevalence of dysplasia and carcinoma arising in SSAs in a recently published article (Lash, Schuler, Genta, J Clin Pathol, 2010) that was accompanied by an editorial highlighting the confusion regarding classification and biology of these polyps.

In our original study we evaluated over 2,100 patients with SSAs. In the present study we have attempted to determine whether our results could be confirmed in the much larger population to which we now have access.

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