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Laboratory Screening of Colorectal Cancer Patients in Routine Practice Identifies Probable Lynch Syndrome Patients at a High Frequency, Even Among Older Patients

Mark Redston and Richard Lash, Miraca Life Sciences Research Institute, Miraca Life Sciences, Newton, MA and Irving, TX

Lynch Syndrome (LS) is a clinically important colorectal and extracolonic cancer predisposition syndrome that may be underdiagnosed in the US. Recently, some experts and advisory groups have recommended routine screening of all newly diagnosed colorectal cancers (CRCs) in order to improve detection of this entity. We analyzed results of a laboratory screening program for LS to determine the prevalence, age distribution and family history characteristics of probable LS patients in a community practice setting.

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