Knowing what isn’t on the slide is as important as what is

Normal villous architecture and surface epithelium. The lamina propria appears normal, but close observation reveals the absence of plasma cells in the lamina propria.

Normal villous architecture and surface epithelium. The lamina propria appears normal, but close observation reveals the absence of plasma cells in the lamina propria.

 

  • 78-year-old woman with chronic diarrhea
  • Upper endoscopy demonstrated numerous small nodules at the duodenal bulb

 

 

 

 

 

Our Diagnosis

  • Absent plasma cells, consistent with an immunodeficiency disorder

Clinician Contacted

  • Patient later confirmed to be IgA deficient

The Miraca Difference

  • Identification of a potentially treatable condition
    • Likely to have been considered “normal” by general pathologists
  • Extremely subtle features recognized that may explain diarrhea, malabsorption, sinopulmonary disease or bacterial infections
  • Information may prevent a reaction to a future blood transfusion

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Miraca’s pathologists have been equally diligent with regard to tailoring their reports to the specifications of each of our physicians. They return reports in a timely fashion, communicate their concerns quickly and have excellent provider support.
— Martha J. Maso, MD, MPH,
Dermatologist, Westwood Dermatology Group, Westwood, N.J.


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