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ERG overexpression and multifocality predict prostate cancer in subsequent biopsy for patients with high-grade prostatic intraepithelial neoplasia

Accepted to Urologic Oncology, 2015. Authors: Rajal B. Shah, M.D., Jianbo Li, Ph.D., Nadeem Dhanani, M.D., Savvas Mendrinos, M.D.

The most important clinical significance of an isolated high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosis is the risk of missed prostate cancer (PCa) in subsequent biopsies. Because most patients with HGPIN do not harbor or develop PCa, clinical, pathological, or molecular markers that predict PCa risk are of clinical significance.

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