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Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes

Published in May 2016 by JAMA The Journal of the American Medical Association. Authors: Kerry B. Dunbar, MD, PhD; Agoston T. Agoston, MD, PhD; Robert D. Odze, MD; Xiaofang Huo, MD, PhD; Thai H. Pham, MD; Daisha J. Cipher, PhD; Donald O. Castell, MD; Robert M. Genta, MD; Rhonda F. Souza, MD; Stuart J. Spechler, MD

Importance  The histologic changes associated with acute gastroesophageal reflux disease (GERD) have not been studied prospectively in humans. Recent studies in animals have challenged the traditional notion that reflux esophagitis develops when esophageal surface epithelial cells are exposed to lethal chemical injury from refluxed acid.

Objective  To evaluate histologic features of esophageal inflammation in acute GERD to study its pathogenesis.

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