InformTx Therapeutic Drug Monitoring


Make Evidence-Based Treatment Decisions

Use InformTx therapeutic drug monitoring (TDM) assays for Remicade® (infliximab), Humira® (adalimumab), Cimzia® (certolizumab pegol), Entyvio® (vedolizumab), Stelara® (ustekinumab), and now Simponi® (golimumab) in patients with inflammatory bowel disease (IBD). InformTx is the first TDM assay in the United States for vedolizumab and certolizumab pegol and golimumab.

What is InformTx?

InformTx therapeutic drug monitoring (TDM) assays measure both drug and anti-drug antibody levels in a patient’s blood.

InformTx assays are available for six biologic drugs used to treat IBD.

  • Remicade® (infliximab)
  • Humira® (adalimumab)
  • Cimzia® (certolizumab pegol)
  • Entyvio® (vedolizumab)
  • Stelara® (ustekinumab)
  • Simponi® (golimumab)

How does InformTx therapeutic drug monitoring work?

InformTx testing uses laboratory-validated ELISA technology. Unique for TDM in the United States, the InformTx report gives you easy-to-interpret results:

InformTx TDM requires five to seven milliliters of peripheral blood in a serum separator tube, and the results are reported within five days.

What is Therapeutic Drug Monitoring? Why Order TDM?

InformTx helps you maximize the efficacy of biologic therapy. Use for all of your IBD patients—whenever you need therapeutic guidance.

  • Optimize at induction to ensure therapeutic drug levels
  • Monitor during maintenance to track drug and anti-drug antibody (ADAb) levels
  • Manage at loss of response/no response to identify reason

Many factors influence individual patient response to biologic therapy:

  • Systemic inflammation
  • Other drug therapies
  • Pharmacogenetic factors
  • Disease phenotype
  • Body mass
  • Immunogenicity
  • Immunomodulators
  • Presence of anti-drug antibodies

Individual response to biologic drugs varies greatly. Variability by patients leads to four patient types: responders, initial responders, partial responders, and non-responders. InformTx enables clinicians to manage all patient types, across six different biologic drugs used to treat IBD.

Ready to Order InformTx Testing?

InformTx testing can be ordered by physicians and other clinicians. Patients who are interested in InformTx therapeutic drug monitoring should contact their healthcare provider to discuss if TDM is right for them.

Clinician Set-Up

Contact a Miraca Life Sciences Client Advocate to order InformTx requisitions and collection kits, at no cost to your practice.

Miraca Client Services Contact Information

Phone: 844.305.2166
Fax: 866.688.3280

Questions? Contact our Client Services team or your Miraca sales representative.

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Meet Our Experts

Richard H. Lash, MD, FCAP, FACG
Richard H. Lash, MD, FCAP, FACG

Chief Medical Officer and Group Head, Medical Practice

Richard H. Lash, MD, FCAP, FACG
James M. Gulizia, MD, PhD

Vice President and Medical Director of GI Pathology

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