Fish Probe Diagnostics

Cytogenetics
This branch of genetics is concerned with the study of the structure and function of the cell, especially the chromosomes

FISH (fluorescence in situ hybridization)
Testing that is used to detect and localize the presence or absence of specific DNA sequences on chromosomes.

Bone Marrow Biopsy
Bone Marrow Examinations can be used to diagnose several Hematologic conditions including: leukemia, multiple myeloma, lymphoma, anemia, and pancytopenia

Normally samples are obtained through both aspiration and trephine biopsy.

  • Aspiration - is a Percutaneous Procedure that takes a sample of semi-liquid bone marrow, examined by a hematology pathologist under a light microscope, analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction(PCR)
  • Trephine biopsy - A Percutaneous Procedure is used to extract a solid piece of bone marrow that is cylindrically shaped that is examined microscopically for cellularity and infiltrative processes

ALL
CEP 4
p16 (9p21) / CEP9
CEP 10
BCR/ABL t(9;22)
MLL (11q23)
TEL/AML1 t(12;21)

MM
CEP 7, CEP 9
CCND1/IgH t(11;14)
Reflex to FGR3/IgH t(4;14)
RB1 (13q14.2)
p53 (17p13.1)

AML
ETO/AML1 t(8;21)
MLL (11q23)
PML/RARA t(15;17)
CBFB inv(16)/t(16;?)
BCR/ABL t(9;22)

NHL
BCL6 (3q27)
c-MYC (8q24)
CCND1/IgH t(11;14)
IgH/BCL2 t(14;18)
MALT1 (18q21)

CLL
ATM (11q22.3)
CEP 12
CCND1/IgH t (11;14)
D13S319 (13q14.3)
p53 (17p13.1)

CML
BCR/ABL t(9;22)
Reflex to ASS1 (9q34.1)

MDS
EGFR1 (5q31)
D7S522 (7q31)
CEP 8
MLL (11q23)
RB1 (13q14.2)
D20S108 (20q12)

MPD
PDGFRA/FIP1L1 (4q12)
PDGFRB (5q33.1)
CEP 8
CEP 9
BCR/ABL t(9;22)

Anaplastic Large Cell Lymphoma
ALK (2p23) t(2;5)

Follicular Lymphoma
IgH/BCL2 t(14;18)

Burkitt's Lymphoma
c-MYC (8q24)

Mantle Cell Lymphoma
CCND1/IgH t(11;14)

Additional Probes
Synovial Sarcoma SYT (18q11.2)
Ewing's Sarcoma ESWR1 (22q12)

Transplant Monitoring
XX/XY for Sex
Mismatched Transplant

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Meet Our Experts


Raul C. Braylan, MD
Riccardo Valdez, MD

Vice President, Medical Director, Hematopathology

Blood Based Disorders


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