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Dermatology Tests

Our team of dermatopathologists provide academic-caliber, definitive diagnoses. As a part of our evaluation, ancillary tests and molecular diagnostics are used most frequently to aid in the precision of these diagnoses.

Test Offering Test Details Indications
Skin biopsy and excision evaluation Evaluation of lesions, inflammatory disorders, and diseases Skin cancer detection and diagnosis and classification of diseases
Trichogram (hair pluck) evaluation Evaluation of a forcible hair pluck specimen using routine and polarizing microscopy Hair shaft abnormality evaluation, and determination of the anagen to telogen hair ratio
Alopecia biopsy evaluation Evaluation of scalp punch biopsies for alopecia, including utilization of Headington technique Evaluation and classification of causes of alopecia
Nail plate, scrapings, nail matrix, and/or nail bed biopsy evaluation Evaluation of nail specimens, with a PAS stain for fungus Onychomycosis and other diseases affecting nails
Direct immunofluorescence Fluorophore-conjugated antibodies to IgG, IgA, IgM, C3, and fibrinogen are used to detect immune complex deposition in fresh tissue skin and mucosal biopsies submitted in Michel’s medium Performed on perilesional skin/mucosa for patients with bullous diseases and lesional skin/mucosa for patients with connective tissue diseases and vasculitis
Melanoma FISH assay Six-probe FISH assay to evaluate for gains and/or losses in chromosomes 6, 11, and 9 that commonly occur in melanoma Detection of differences in chromosomal aberrations between melanoma and nevi, to improve diagnostic accuracy in the classification of ambiguous melanocytic tumors
HPV genotyping In situ hybridization studies for high and low-risk HPV To determine presence of low-risk and/or high-risk HPV in the lesion
DNA mismatch repair (MMR) analysis MMR protein immunohistochemical stains (MLH1, MSH2, MSH6, and PMS2) Performed on sebaceous tumors to identify patients with HNPCC/Lynch/Muir Torre Syndrome
Wide variety of immunohistochemistry and special stains Immunohistochemical stains and chemical special stain are performed on formalin-fixed tissue Diagnosis and classification of tumors and nonneoplastic diseases
Molecular testing for cutaneous hematologic malignancies Comprehensive ancillary tests using FISH, PCR, and in situ hybridization techniques Diagnosis and classification of lymphomas and leukemias
Second opinion service Expert consultation performed on slides from outside laboratories For difficult and unusual cases

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